Publications
Chitogel is clinically proven to significantly reduce ostial stenosis, minimise adhesions and act as an adjunct to aid in the natural healing process.
The development of Chitogel has been supported by a long list of scientific studies, published in international peer-reviewed journals:
Key clinical evidence
Ha T, Valentine R, Moratti S, Hanton L, Robinson S, and Wormald P-J. Int Forum Allergy Rhinol. 2018 Jul;8(73):573-80.
This prospective, blinded, randomized controlled trial compared the following treatments:
- Chitosan-dextran (CD) gel (Chitogel)
- Control (no treatment)
- CD gel (Chitogel) with 1 mg/2 mL budesonide
- Topical steroid cream (betamethasone valerate)
Complete list of supplementary evidence:
Chitogel following endoscopic sinus surgery promotes a healthy microbiome and reduces postoperative infections.
Megow A, Alsuliman Y, Bouras G, et al.
Int Forum Allergy Rhinol. 2022;1-15.
Chitogel improves long-term health economic outcomes following endoscopic sinus surgery in severe chronic rhinosinusitis patients
Barber JM, Bouras G, Robinson GS and Robinson SR (2024).
Front. Health Serv. 4:1196499
A Topical Hydrogel With Deferiprone And Gallium-Protoporphyrin Targets Bacterial Iron Metabolism And Has Antibiofilm Activity
Richter, N. Thomas, J. Claeys, J. McGuane, C. Prestidge, T. Coenye, P.-J. Wormald, S. Vreugde. Antimicrobial Agents and Chemotherapy, 2017
Deferiprone And Gallium-Protoporphyrin Have The Capacity To Potentiate The Activity Of Antibiotics In Staphylococcus Aureus Small Colony Variants.
Richter, N. Thomas, C. Prestidge, T. Coenye, P.-J. Wormald, S. Vreugde. Frontiers in Cellular and Infection Microbiology, 2017
Chitosan Dextran Gel As An Anti Adhesion Agent In A Postlaminectomy Spinal Sheep Model.
Rajiv S, Drilling A, Bassiouni A, Harding M, James C, Robinson S, Moratti S, Wormald PJ.
J Clin Neurosci. 2017 Jun;40:153-156.
Safety And Efficacy Of Chitosan-Dextran Hydrogel In The Middle Ear In An Animal Model.
Ünsaler S, Başaran B, Öztürk Sarı Ş, Kara E, Değer K, Wormald PJ.
Audiol Neurootol. 2016;21(4):254-260.
Characterization Of The In Vivo Host Response To A Bi-Labeled Chitosan-Dextran Based Hydrogel For Postsurgical Adhesion Prevention.
Cabral JD, McConnell MA, Fitzpatrick C, Mros S, Williams G, Wormald PJ, Moratti SC, Hanton LR.
J Biomed Mater Res A. 2015 Aug;103(8):2611-20.
The Use Of Chitosan-Dextran Gel Shows Anti-Inflammatory, Antibiofilm, And Antiproliferative Properties In Fibroblast Cell Culture.
Paramasivan S1, Jones D, Baker L, Hanton L, Robinson S, Wormald PJ, Tan L. Am J Rhinol Allergy. 2014 Sep-Oct;28(5):361-5.
A Blinded Randomized Controlled Trial Evaluating The Efficacy Of Chitosan Gel On Ostial Stenosis Following Endoscopic Sinus Surgery.
Ngoc Ha T, Valentine R, Moratti S, Robinson S, Hanton L, Wormald PJ.
Int Forum Allergy Rhinol. 2013 Jul;3(7):573-80.
Synthesis, Physiochemical Characterization, And Biocompatibility Of A Chitosan/Dextran-Based Hydrogel For Postsurgical Adhesion Prevention.
Cabral JD, Roxburgh M, Shi Z, Liu L, McConnell M, Williams G, Evans N, Hanton LR, Simpson J, Moratti SC, Robinson BH, Wormald PJ, Robinson S.
J Mater Sci Mater Med. 2014 Dec;25(12):2743-56.
The Efficacy And Safety Of Chitosan Dextran Gel In A Burr Hole Neurosurgical Sheep Model.
Rajiv S, Harding M, Bassiouni A, Jardeleza C, Drilling A, James C, Ha T, Moratti S, Robinson S, Wormald PJ. Acta Neurochir. 2013 Jul;155(7):1361-6
Use Of A Modified Chitosan-Dextran Gel To Prevent Peritoneal Adhesions In A Porcine Hemicolectomy Model.
Lauder CI, Strickland A, Maddern GJ. The Journal of surgical research. 2012;176(2):448-54.
Use Of A Modified Chitosan-Dextran Gel To Prevent Peritoneal Adhesions In A Rat Model.
Lauder CI, Garcea G, Strickland A, Maddern GJ. The Journal of surgical research. 2011;171(2):877-82.
The Efficacy Of Hemostatic Techniques In The Sheep Model Of Carotid Artery Injury.
Valentine R, Boase S, Jervis-Bardy J, Dones Cabral JD, Robinson S, Wormald PJ.
Int Forum Allergy Rhinol. 2011 Mar-Apr;1(2):118-22. doi: 10.1002/alr.20033.
Nasal Dressings After Endoscopic Sinus Surgery: What And Why?
Valentine R, Wormald PJ.
Curr Opin Otolaryngol Head Neck Surg. 2010 Feb;18(1):44-8
The Efficacy Of A Novel Chitosan Gel On Hemostasis And Wound Healing After Endoscopic Sinus Surgery.
Valentine R, Athanasiadis T, Moratti S, Hanton L, Robinson S, Wormald PJ.
Am J Rhinol Allergy. 2010 Jan-Feb;24(1):70-5.
The Efficacy Of A Novel Chitosan Gel On Hemostasis After Endoscopic Sinus Surgery In A Sheep Model Of Chronic Rhinosinusitis.
Valentine R, Athanasiadis T, Moratti S, Robinson S, Wormald PJ.
Am J Rhinol Allergy. 2009 Jan-Feb;23(1):71-5.
Safety And Efficacy Of Topical Chitogel-Deferiprone-Gallium Protoporphyrin In Sheep Model
Ooi ML, Richter K, Drilling AJ, Thomas N, Prestidge CA, James C, Moratti S, Vreugde S, Psaltis AJ and Wormald P-J. Front. Microbiol. (2018) 9:917.